Citation : Rishi Arora,Alan H. Kadish.Role of the Autonomic Nervous System in the Creation of Substrate for Atrial Fibrillation .JAFIB.2008 Dec;Volume 1 Issue(4): 236-243.
Atrial fibrillation (AF) is the most common sustained arrhythmia disturbance and is associated with significant morbidity and mortality. In recent years, the pulmonary veins (PVs) and posterior left atrium (PLA) have been shown to play a significant role in the genesis of AF.
These regions have been shown to possess unique structural, electrophysiological and calcium (Ca2+) handling characteristics, all of which appear to contribute to substrate for AF.
The pathophysiology of AF is complex, and several mechanisms have been thought to contribute to the electrophysiologic and structural substrate for this arrhythmia. These mechanisms include fibrosis, stretch, inflammation and oxidative stress. In addition, neurohumoral factors have also been invoked for their possible contribution to the creation of electrophysiologic substrate for AF [3, 4]. An important neurohumoral factor that has been studied fairly extensively for its involvement in AF is the autonomic nervous system.
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